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Mapping clinical barriers and evidence-based implementation strategies in low-to-middle income countries (LMICs)

Bhatti J.S., Khullar N., Mishra J., Kaur S., Sehrawat A., Sharma E., Bhatti G.K., Selman A., Reddy P.H

Cells were preincubated in glucose-free or 10 mM glucose containing Hanks Balanced Salt Solution (HBSS) (1.3 mM CaCl 2 , 0.8 mM MgSO 4 , 5.4 mM KCl, 0.44 mM KH 2 PO 4 , 4.2 mM NaHCO 3 , 137 mM NaCl, 0.34 mM Na 2 HPO 4 pH 7.4) for 1 h at 37C and 5% (v/v) CO 2

the subject is a male or female human being of any age, sex or race

In vivo and in vitro models, it was found that in the IDH1 mutant glioma cells intervened by triptolide, the transcriptional activity of Nrf2 was suppressed, and the expression of genes related to glutathione anabolic metabolism (GCLC, GCLM, and SLC7A11) was significantly down-regulated

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