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10.1038/s41586-022-04687-0 [DOI] [PMC free article] [PubMed] [Google Scholar] Thompson ED, Hogstrand C, & Glover CN (2018)

In this study, plasma glutathione levels increased to 300% of baseline levels after one hour, followed by a decrease to approximately 200% of baseline levels within the next three hours

2018 Jul;154(1):196-206

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College of Veterinary Medicine, University of Sulaimani, Sulaimani, Iraq This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Methods: SACRED is a phase III, prospective, multi-center, double-blind clinical trial (NCT03654053) that enrolled patients with compensated cirrhosis and clinically significant portal hypertension (CSPH), stratified upon concomitant use of nonselective beta-blockers, randomized enrollees 1:1 to simvastatin 40 mg/day versus placebo for up to 24 months at 11 Veterans Affairs Medical Centers in the United States