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Aging is accompanied by BBB breakdown, and instead of being region-specific as in neurological diseases (e.g., hippocampus in Alzheimers disease), it is zonation-specific (capillaries are more affected than other vessel types) (Zhao et al., 2020)

These so called cutoffs are derived from serum MMA concentrations compiled from US NHANES 20032006 data in which the central 95% reference intervals (2.5th to 97.5th percentile) for serum MMA concentrations were presented (Pfeiffer et al., 2013)

Stay well-hydrated and ensure adequate micronutrient intake, particularly vitamin C, zinc, and copper for collagen formation

PMID: 21779527

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