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coli strains carrying the polyketide synthase pathogenicity island can produce colibactin, a genotoxin that causes DNA damage and activates STAT3 signaling in epithelial cells

The latter represents a central perfusion deficit or hemodynamic disorder, characterized by distinct mechanisms, although both conditions may coexist

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Cytotoxic edema: monitoring its magnitude and contribution to brain swelling

Along with an assessment for pathognomonic red blood cell morphologies, such as spherocytes or schistocytes, examination of the white blood cells and platelets for coexisting hematologic or malignant disorders is essential