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Description

Small molecule nicotinamide N-methyltransferase inhibitor activates muscle stem cells and progenitor cell function

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Previous work has reported relatively increased Firmicutes and Proteobacteria and decreased Bacteroidetes in mice on an HFD, regardless of concomitant obesity (weight gain was minimized using a RELM knockout mouse 78 ) 78,79

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Investigated in body-composition biomarker research under supervised protocols

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This inhibition reduces intracellular 1-methylnicotinamide (1-MNA) production (EC50 = 2.3 M) and preserves nicotinamide availability for the NAD+ salvage pathway

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