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A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses PMC A new twist to an old tale: novel insights into the differential toxicities of acetaminophen and its regioisomer N acetyl meta aminophenol (AMAP) Archives of Toxicology Springer Nature Link Pharmacokinetics of Paracetamol BioRender Science Templates Zonation of drug conjugation metabolism in vitro. (a) Acetaminophen Download Scientific Diagram 3 (glutathion S yl)acetaminophen C18H24N4O8S CID 83998 PubChem
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