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10.1093/sleep/30.11.1445 107

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Furthermore, GSDMD-induced pyroptosis is regulated by caspase-8

Thus, modulation of SPARC production may have potential implications for postinfarction healing [40], and decorin has a protective role in several cardiac diseases, including atherosclerosis, hypertrophy, and myocardial infarction [41]

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This approach may approximate the direct application scenario but poorly represents the pre-aged state of materials from indirect release pathways, which are arguably the more widespread source of environmental loading