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Figure 4 Figure 5 3.5 Cystine increases intracellular ferrous ion concentrations and elevates ROS levels following gentamicin treatment Despite their specific drugtarget interactions, bactericidal antibiotics are known to stimulate the production of highly deleterious hydroxyl radicals in bacteria, a process that is facilitated through the Fenton reaction involving intracellular ferrous iron (Kohanski et al., 2007)

Studies indicate that elevated levels of metals such as Fe, Cu, Mn, and Zn can damage the UPS and are associated with OS, mitochondrial dysfunction, and protein misfolding [63]

Sorensen, J

Ibs KH, Rink L

Some users describe improvements in pain or mobility within days or weeks, but individual responses vary widely

doi: 10.5306/wjco.v7.i1.122 9 AllesMCGardiner-GardenMNottDJWangYFoekensJASutherlandRLet al