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The elevated plasma ALT and AST activity was complemented with high liver microsomal membrane fluidity, ROS production, and variation in the hepatocyte histogram [2] ( Figure 3 )

4.3 Cancer 4.3.1 TAMs and immunosuppression TAMs shape an immunosuppressive microenvironment by polarizing towards the M2 phenotype, a process driven by metabolic reprogramming, dysregulated signaling pathways, and intercellular interactions