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Zhang L, Jin H, Guo X, Yang Z, Zhao L, Tang S, Mo P, Wu K, Nie Y, Pan Y, Fan D

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In fact, some doctors believe that the coffee actually aggravates the colons of some coffee enema users, leaving behind blisters and damage in the colon

doi: 10.1016/j.prp.2025.155903 95 MontaigneDButruilleLStaelsB

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Loss of DNA methylation in the CDH3 gene promoter results in the overexpression of P-cadherin in colorectal and breast carcinomas, which decreased cell polarity and promotes the invasion and migration of colorectal and breast cancer cells (Paredes et al., 2005