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Science 312(5777):11711175 Al-Husein B et al (2012) Antiangiogenic therapy for cancer: an update

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This structure reveals that only one IGF1 molecule binds the -shaped asymmetric IGF1R dimer

The bacteria must be susceptible to the antibiotic for a full recovery

This is particularly relevant in tumors with high mutational burden, such as microsatellite instability-high (MSI-H) cancers, where frameshift mutations frequently generate PTC-containing transcripts