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However, in T2D pathology, insulin resistance and excessive free radical production act as synergistic mediators of pathological liver conditions such as hepatic ischemia, hepatic cirrhosis, non-alcoholic fatty liver disease, obstructive cholestasis, and hepatocellular carcinoma[]

Mixing them creates stability and degradation issues that compromise the efficacy of both compounds

Most studies involve small participant numbers, short follow-up periods, and lack robust placebo controls, limiting the strength of conclusions

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Which tissues respond best (muscle, endocrine, kidney, brain)

Immune or clearance burden: a rapid wave of dying cells must be cleared, which could stress the system