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2021 [cited 2025 Mar 14]

3.1 Strategies to overcome resistance mediated by drug transporters in mCRC Due to the crucial role played by ABC transporters in cancer chemoresistance, over the years, extensive efforts have been made to develop therapeutic approaches to block or modulate their activity to increase the concentration of anti-cancer drugs within the cells and re-establish the drug sensitivity of resistant cancer cells (Ozols et al., 1987

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Mitochondria are vital organelles responsible for ATP production and are integral in regulating oxidative stress, calcium homeostasis, apoptosis and synaptic plasticity (13,14)

Body Composition and Fat Metabolism (Weeks 4 to 8) GH activates lipolysis, particularly in visceral and subcutaneous fat