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Knockout of either Grx5 or Grx3 leads to iron accumulation in cells [31,136,137] , impaired FeS cluster biosynthesis [138] , and deregulated iron homeostasis via IRPs [31,137,139] (Figure 4)

Accumulating evidence suggests that overstimulation of glutamate receptors, impaired mitochondrial functions, and oxidative stress are interconnected events that lead to oxidative neuronal injury in patients with autism [81, 82]

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In lung cancer cell lines, the expression of FSP1 is negatively correlated with the sensitivity to RSL3, ML162, or ML210 (GPX4 inhibitors) [68]

Philippines Glutathione Market is valued at around $0.8 Mn in 2022 and is projected to reach $1.4 Mn by 2030, exhibiting a CAGR of 6.93% during the forecast period 2023-2030

Notably, the concentration of e-CAT in humans was higher than in other mammalian species, exceeding five to six times the levels in goat and sheep