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Experiences in fragment-based lead discovery

J.RochaS.CoimbraS.CatarinoC.Rocha-PereiraP.Bronze-da-RochaE.et al (2019)

Nature 596(7873):E13E13 Marbach-Breitrck E, Rohwer N, Infante-Duarte C, Romero-Suarez S, Labuz D, Machelska H, Kutzner L, Schebb NH, Rothe M, Reddanna P, Weylandt KH, Wieler LH, Heydeck D, Kuhn H (2021) Knock-in mice expressing a 15-lipoxygenating Alox5 mutant respond differently to experimental inflammation than reported Alox5(-/-) mice