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Additionally, a 7-year prospective study found that while NSW alone was not significantly associated with chronic pain or CRP levels, the combination of NSW and moderately elevated CRP was associated with an increased risk of chronic pain and pro-inflammatory background 150

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However, more robust clinical investigations are required to confirm these findings and establish therapeutic applications ( 2 Antioxidative effects of PYC PYC exhibits potent antioxidant properties by effectively scavenging reactive oxygen and nitrogen speciesincluding superoxide (O 2 ), nitric oxide (NO), peroxynitrite (ONOO ), and hydroxyl radicals (OH)thereby counteracting oxidative stress induced by excessive reactive oxygen species (ROS) production (Ren et al., 2017

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Factors of the GH/IGF-1 axis known to influence ageing