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In addition to the ubiquitous expression of the IGFs, these growth factors circulate in high concentrations and, because of the rich blood supply of the cortical and trabecular skeleton, allow exposure of bone cells to these peptides

Aug 31 2022;31(4):232-242

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The compounds ability to cross the blood-brain barrier and accumulate in mitochondria-rich tissues has made it an interesting candidate for therapeutic applications targeting mitochondrial health Figure 3 [71]

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