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In addition to a reduction of GPx3 levels, we also observed in our sibling cohort a large deficiency in cystine, the limiting factor to produce glutathione, which is required as a reducing agent for GPx3 and the entire glutathione peroxidase family 30,51

6 Extracellular acidification of gsh2 mutants is independent of l-DOPA and GSH pathway metabolites influence melanin formation

Research Foundation of Sichuan Medical Association (2024HR40)

To view a copy of this licence, visit About this article Cite this article Han, M., He, W., Zhu, W

Polynucleotides encoding these polypeptide fragments are also encompassed by the invention