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Hypoxic tumor microenvironment activates GLI2 via HIF-1 and TGF-2 to promote chemoresistance in colorectal cancer

DiNicolantonio, PharmD, Wegmans Pharmacy, Ithaca, NY, observes, Although therapies for acute coronary syndrome (ACS), including percutaneous coronary intervention, dual antiplatelet therapy, b-blockers (BBs), statins, angiotensin-converting enzyme inhibitors (ACEIs), omega-3 fatty acids, and cardiac rehabilitation, have markedly improved clinical outcomes, adverse cardiovascular (CV) events still occur too frequently after ACS

Acknowledgements We thank the Research Support Center for Human Disease Models, Graduate School of Medicine, Kyushu University, for technical assistance

doi: 10.3390/v12010066 59 Otulak-KozieK.KozieE.PrzewodowskiW.CiackaK.PrzewodowskaA

Together, they create a sustained and balanced increase in circulating GH and IGF-1 levels