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Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion may not be useful due to high protein binding

Many of these home kits only measure total B12, and not other markers in your blood, such as methylmalonic acid or homocysteine, which are better signs of deficiency, Ren says

No relevant literature was identified regarding the diagnostic test accuracy, clinical utility, and cost-effectiveness of serum folate testing in people with suspected folate deficiency

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