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Nat Biotechnol 21(8):914919 Song WY, Park J, Mendoza-Cozatl DG, Suter-Grotemeyer M, Shim D, Hortensteiner S, Geisler M, Weder B, Rea PA, Rentsch D, Schroeder JI, Lee Y, Martinoia E (2010) Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters

It encompasses the structural and functional aspects of the cellular surroundings, but also the presence of metabolites such as glucose, amino acids and lipids within the TME, as well as environmental factors such as hypoxia and acidity (81)