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A need for NAD+ in muscle development, homeostasis, and aging

Impairment of several immune functions and redox state in blood cells of Alzheimer's disease patients

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Oral magnesium treatment in diabetes has also been reported to potentiate the antioxidant defence system

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However, in GDH 1 knock-out mice (only humans express GDH 2) most functions, except the already mentioned reduced glutamate oxidation in cultured astrocytes, are remarkably intact (Frigerio et al., Table 2 Oxygen consumption rates as indications of kinetics of glutamate-dehydrogenase and aspartateglutamate transferase activities in non-synaptic mitochondria from the rat