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h , CRISPR-A mediated activation of Erbb2 , CRISPR-KO mediated knockout of Trp53 , and CRISPR-KOALA mediated combined perturbation accelerates mammary tumour onset in Pik3ca +/H1047R

Except for the normal group, the other four groups of mice were injected intraperitoneally with D-GalN (400 mg/kg) and LPS (100 g/kg) to induce the ALF model

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Compared to the control mice, urinary levels of cholic acid, lithocholic acid and -muricholic acid were significantly elevated in mice treated with APAP, while ursodeoxycholic acid and -muricholic acid were significantly decreased