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Baliga notes that it is proven to be a free radical scavenger, to increase glutathione S-transferase, decrease excessive Phase 1 liver enzymes (which can convert chemicals into carcinogens), decrease lipid peroxidation, and is anti-inflammatory, anti-mutagenic, and immunomodulatory

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Kelso GF, Maroz A, Cochem HM, Logan A, Prime T.A, Peskin AV, et al., A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic, Chem Biol 2012:19: 12371246

Currently, FDA approval exists only for submental (under-chin) use, so arm treatments are considered off-label

doi: 10.4049/jimmunol.1101772