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Describe the provable modification of the KER (also quantitatively, if known)

Toshikuni et al

PLoS Negl Trop Dis (2010) 4(8):781

Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes. Frontiers in bioengineering and biotechnology vol

Hypoxia leads to the activation of many downstream gene targets, which mainly rely on hypoxia inducible factors (HIFs) mediated signaling pathways to adapt to hypoxic conditions