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Moreover, traditional drug delivery systems (DDSs)primarily oral tablets and intravenous injectionsfail to address localized MSU crystal deposition or provide sustained drug release, leading to recurrent flares and chronic joint damage (Mohamad et al., 2025

Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments

and Hariri, M., 2019

2 Western blot : Target proteins or interacting proteins were detected using specific antibodies

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Current evidence indicates that melanocortin-4 receptor (MC4R) activation serves as the primary driver of its sexual function effects, with additional contributions from MC3R and MC1R pathways