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Strikingly, in the active structure of the c-MET/HGF dimeric complex, only HGF I simultaneously recruits two c-METs by using two distinct surfaces localized on the opposite sides of this HGF (Fig

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The cleavage of collagen IV by MMP-2 and MMP-9, which are prevalent in the basement membrane, plays a crucial role in the invasion and spread of SCC

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