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Mechanistically, autoantibodies and interferon- present in the serum induce neutrophil ferroptosis through enhanced binding of the transcriptional repressor CREM to the glutathione peroxidase 4 ( Gpx4 , the key ferroptosis regulator) promoter, which leads to suppressed expression of Gpx4 and subsequent elevation of lipid-reactive oxygen species

Pioglitazones mechanism of action includes suppressing inflammatory responses and inhibiting the activation of hepatic stellate cells, which are key players in developing liver fibrosis

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Oxidative stress with an activation of the reninangiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction

Identification of the bladder dose and volume constraints to control late urinary toxicity after external beam radiotherapy for prostate cancer

H358 matrix was additionally normalized by median centering prior statistical analysis