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separated a kava extract in three fractions (A, B and C) using HPLC to determine which active fraction, and consequently which components, could be responsible for kavas chemopreventive efficacy in A/J mice in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis model [100]

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In studies utilizing microarray technology, FetuinB acts as an FXR agonistregulated gene ( Figure 1 )

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