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Lana JV, Rios A, Takeyama R, Santos N, Pires L, Santos GS, Rodrigues IJ, Jeyaraman M, Purita J, Lana JF (2024) Nebulized glutathione as a key antioxidant for the treatment of oxidative stress in neurodegenerative conditions

J., Gao, X., Jones, A

10.1096/fj.202101385RR 79 Pankeviit-BukauskienM.MikalayevaV.vikasV.SkeberdisV

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These results suggest that Fasn inhibition reduces ROS levels via the Nrf2/HO-1 pathway, thereby preventing NLRP3 inflammasome activation and mitigating the inflammatory response and cell pyroptosis induced by Ang II

Metabolomic analysis indicated that the resulting levels of reduced GSH were significantly lower in wild-type mice on MET restriction compared to the levels in wild-type mice fed 1.3% MET and to dwarf mice on either diet (Figure 3)