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Since vitamin B 12 deficiency can cause an anemic state in the body by attenuating the immune system, patients with vitamin B 12 deficiency are more susceptible to opportunistic infections such as candidiasis [29]

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I Physicochemical compatibility between the chitosan used as a mucoadhesive agent and the methylcobalamine is carried out by making physical mixture with kBr pellet and allow them to react for 24 hr in dark condition them in this mixture analysed and infrared radiation from 400-4000 cm