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doi: 10.1158/1535-7163.MCT-13-0870

Springer, Boston

Rictor +/+ and Rictor -/- MEFs were provided by D.A

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found that knockdown of TLR4 or NADPH oxidase-4 (NOX4) during the development of heart failure could lead to increased expression of GPX4 and FTH1, reduced intracellular unstable iron, decreased lipid peroxidation, inhibition of left ventricular remodeling, and improvement of ventricular function