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A systems-based approach and customized drug testing techniques may be required to gain a deeper understanding of the underlying mechanisms and causes ( Integration of pharmacogenomics, metabolomics and microbiomics: Path to personalized metformin therapy Until recently, personalized medicine in T2D has predominantly focused on variation in DNA sequence

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Asiaticoside (MA) inhibits UV-induced hyperpigmentation by mediating the COX-2 and PGE pathways by inhibiting PAR-2 expression (Jung et al., 2013)

Compounds such as curcumin 21 , resveratrol 22 , and quercetin 23 were reported to possess neuroprotective, anti-inflammatory, and antioxidant activities that could address the pathological manifestations of PD 24