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Reconstitution of telomerase activity combined with HPV-E7 expression allow human preadipocytes to preserve their differentiation capacity after immortalization

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Its short 23 hour half-life means lipolytic effects are transient and must coincide with low insulin (fasted state) and high oxidative demand (exercise) to prevent FFA re-esterification

doi: 10.1038/s41571-020-00462-0 68 ZengLYangKYuGHaoWZhuXGeAet al

Major organs (the heart, liver, spleen, lungs, and kidneys) were fixed in 4% paraformaldehyde for histological analysis

Sci Rep 6:20391 Fries GR, Saldana VA, Finnstein J, Rein T (2023) Molecular pathways of major depressive disorder converge on the synapse