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The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious

& Susumu, G

Finally, the review identifies persistent challenges including phytochemical standardization and the translational gap between preclinical and clinical research, and proposes future research directions focused on rigorous clinical trials, mechanistic studies and sustainable exploitation within a circular bioeconomy framework

Marzagalli M, Ebelt ND, Manuel ER

V., Utsumi, H

The regulation of senescence by AMPK mainly links to the SIRTs family, and the intracellular signals generated by AMPK are important core substances that inhibit the senescence of cardiomyocytes