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Fatty acid-binding protein 5 aggravates psoriasis and psoriasis-like disease through ferroptosis

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Study confirms that inhibition of mTORC1 suppresses SREBP1 transcription and promotes ferroptosis sensitivity of cells [96]

In addition, lactate alone or combined with tumor-derived colony-stimulating factor-2 (CSF2) induces macrophage polarization towards tumor-associated macrophages M2-like macrophages, which are more supportive of tumor progression compared with immune surveillance polarization (M1) [128,131]

Cold Spring Harbor Perspect