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Very high doses of 5mg (5,000mcg) or more can cause skin issues such as acne or rosacea flare-ups and, in the case of methylcobalamin specifically, anxiety and jitters

Monitoring Recommendations For extended use protocols, periodic laboratory monitoring adds an extra layer of safety

A : Rition 5000 mg should be administered once a week, either intravenously or intramuscularly, as per the guidance of a healthcare professional

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10.1021/acs.jnatprod.3c00711 178 PaivaL

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