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Preclinical Characterization of SAR650984, a Humanized Anti-CD38 Antibody for the Treatment of Multiple Myeloma: P-288

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La accin especfica del pptido sobre los adipocitos que expresan NNMT permite una modificacin metablica localizada sin una sobreestimulacin sistmica generalizada, lo que representa un modelo nico para estudios de modulacin selectiva de la masa grasa

However, the mutant strains expressing non-phosphorylatable- vadK:vadK His422Ala , phosphomimetic vadK:vadK His422Asp or a non-functional ATP-binding site vadK:vadK Arg106Lys were unable to grow (Appendix Fig