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doi: 10.3389/fnmol.2015.00077 56 BrsJPGuillot de SuduirautIZanolettiOMonariSMeijerMGrosseJet al

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By describing the endogenous and exogenous elements involved in novel cell death disulfidptosis and identifying associations between disulfidptosis and CNS disorders, such as neurodegenerative diseases, gliomas, and ischemic stroke, this review summarizes disulfidptosis-related genes involved in neurodegenerative diseases, gliomas, and ischemic strokes and discusses how disulfide stress and redox imbalance contribute to the onset and progression of CNSD

In contrast, downregulation of genes encoding HLA class 2 ( HLA-DRA, HLA-DPA1, HLA-DMA, DYNLL1) was found in COVID-19 ECs (Supplementary Fig