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The National Cancer Institute conducted chemoinformatics analysis of 60 cell lines and showed a negative correlation between xCT expression levels and sensitivity to compounds associated with GSH-mediated resistance, which indicated that xCT expression induces chemoresistance via GSH-mediated ROS detoxification activity (82)

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Evidence suggests that A can enhance neuronal iron uptake and promote GPX4 degradation, while lipid peroxidation products may accelerate tau hyperphosphorylation