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The proposal is straightforward: Move toward biomarker-driven patient stratification Design more flexible, biology-informed clinical trials Align regulatory approaches with what already works in oncology and dementia Dementia offers a useful reference point

It increases the working efficiency of mitochondria, which has an important role in the cell

Tendon strength comes from parallel fiber alignment and proper cross-linking between collagen molecules

Davis, K

Most of the disorders affect the genes responsible for the bodys ability to produce collagen, a protein important for maintaining tissue structure

Therefore, the relationship between mechanical loading and cell function is considered to be a key component of intervertebral disc function and dysfunction