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By contrast, uridine supplementation significantly rescued these phenotypes in aged oocytes (Fig

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Dose may be titrated gradually and given up to twice a week depending on the condition and desired outcomes

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10.1186/s40199-014-0072-7 188 SiddiquiS

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Excitotoxicity causes massive calcium influx, activating calcium-dependent proteases and NOS, which rapidly trigger MMP-9 activation, leading to the swift degradation of tight junctions and the basement membrane (166)

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4C, compare lanes 7 to 5, and Fig

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