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Chen EI, Hewel J, Krueger JS, Tiraby C, Weber MR, Kralli A, Becker K, Yates JR, Felding-Habermann B: Adaptation of energy metabolism in breast cancer brain metastases

Increased DNA damage can lead to increased expression of cyclin-dependent kinase inhibitor p21 and DNA damage marker -H2A.X and induce cell apoptosis, leading to the activation of apoptotic proteins (caspase3, caspase7, poly (ADP-ribose) polymerase 1 (PARP1), etc.)