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Persistent TNF- action has been related to the generation of oxidative stress and tissue remodelling, thereby relating COPD pathogenesis to the extremes of the innate immune system [18]

Another important thiol is glutathione, a tripeptide responsible for protecting cells from oxidative stress and detoxifying harmful substances

10.1126/science.1636093 79

Karim M, Jackson P, Jackowski S

Moreover, in cells exposed to hyperosmotic conditions, choline uptake is enhanced in mitochondria in order to resist volume reduction and osmotic water loss