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However, owing to their multifaceted action mechanisms in tackling resistant cancer cells, further investigation is required to clarify the resulting non-specificity, potential toxicity in normal tissues, and detailed pharmacokinetics

(2001) Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding

Naturally or synthetic chemotherapeutic agents exert their effects through oxidation or modification of cysteine thiol groups present in the cellular signal molecules mediated by phosphatases and kinases

52 The resulting loss of functional ATP7A in the intestine leads to reduced Cu efflux into the blood, an accumulation of Cu in enterocytes, and generalized severe systemic Cu deficiency

Studies have found that berberine has an antidepressant effect (Kulkarni and Dhir, 2008

J., Cheung, R