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Thus, if manageable safety and tolerability profiles are demonstrated in humans with renal impairment and sufficient urinary excretion is observed, surgical patients with renal impairment may be included as part of the target indication, given the prevalence of moderate to severe renal impairment of ~ 10% [13, 14]

doi:10.1080/00221309.1988.9711083

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10.1016/j.intimp.2006.11.006