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The Monash University trial that established its safety profile used 1mg daily for 12 weeks without adverse effects on glucose metabolism or thyroid function

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This effect is usually reversible after stopping treatment, but men who wish to have children should discuss it with their doctor

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Theoretically, the intracellular assimilation of folic acid via dihydrofolate reductase might enhance thymidylate synthetase by bypassing the methylfolate trap, thereby allowing cellular proliferation to progress temporarily