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Adaptation of the maternal intestine during lactation

Altogether, our work revealed a paradigm for the autoregulatory control of metabolic homeostasis in organelles

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MCC microcrystalline cellulose mannitol mannitol starch sorbitol and/or lactose lactose lactose the solid oral pharmaceutical composition may comprise one or more solubility enhancers, such as, e.g., poly(ethylene glycol), including poly(ethylene glycol) having a molecular weight in the range of about 200 to about 5,000 Da, ethylene glycol, propylene glycol, non-ionic surfactants, tyloxapol, polysorbate 20, polysorbate 80, macrogol-15-hydroxystearate, phospholipids, lecithin, dimyristoyl phosphatidylcholine, dipalmitoyl phosphatidylcholine, distearoyl phosphatidylcholine, cyclodextrins, a-cyclodextrin, P-cyclodextrin, y-cyclodextrin, hydroxyethyl-P-cyclodextrin, hydroxypropyl-p-cyclodextrin, hydroxyethyl-y-cyclodextrin, hydroxypropyl-y-cyclodextrin the solid oral pharmaceutical composition may comprise one or more pharmaceutically acceptable carriers

Methods: We crossed Cflar FF ;Alb-Cre mice with Fgf18 FF mice, resulting in the generation of hepatocyte-specific Cflar and Fgf18 double-deficient ( Cflar LKO ;Fgf18 LKO ) mice