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doi: 10.1056/NEJM200107123450202 20

Procedures This study employed a randomized, double-blind, placebo-controlled, crossover clinical design

& Tannock, I

Furthermore, studies have found that HDAC (histone deacetylase), epigenetic regulators that remove acetyl groups from histones, are closely associated with endothelial dysfunction, inflammation, and myocardial fibrosis through their epigenetic regulatory actions (Jin et al., 2017a)