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162,163 In one study, approximately half of patients treated with VNS had a clinical response (defined as a 50% or greater reduction in depression scores) and nearly 40% were in remission after two years

Fourth, predictive biomarkers capable of reliably stratifying patients for immunotherapy and targeted treatments remain suboptimal, contributing to treatment variability and overtreatment in many cases (329)

Furthermore, the initiation codon must be in phase with the reading frame of the desired coding sequence to ensure translation of the entire insert

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